Applying knowledge in the right context is the most powerful lever businesses can use to become agile, creative, and resilient. Knowledge graphs add context, meaning, and utility to business data. They drive intelligence into data for unparalleled automation and visibility into processes, products, and customers. Businesses use knowledge graphs to anticipate downstream effects, make decisions based on all relevant information, and quickly respond to dynamic markets. In this report for chief information and data officers, Jesus Barassa, Amy E. Hodler, and Jim Webber from Neo4j show how to use knowledge graphs to gain insights, reveal a flexible and intuitive representation of complex data relationships, and make better predictions based on holistic information.